Gianluca's Publications

 

37. Civenni G., Carbone G.M., Catapano C.V. Overview of Genetically Engineered Mouse Models of Prostate Cancer and Their Applications in Drug Discovery. Curr Protoc Pharmacol. 2018 Jun;81(1):e39.

36. Chen J., Guccini I., Di Mitri D., Brina D., Revandkar A., Sarti M., Pasquini E., Alajati A., Pinton S., Losa M., Civenni G., et al. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018 Feb;50(2):219-228.

35. Janouskova H., El Tekle G., Bellini E,. Udeshi N.D., Rinaldi A., Ulbricht A., Bernasocchi T., Civenni G., et al. Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. Nat Med. 2017 Sep;23(9):1046-1054.

34. Genini D., Brambilla L., Laurini E., Merulla J., Civenni G., Pandit S., D'Antuono R., Perez L., Levy D.E., Pricl S., Carbone G.M., Catapano C.V. Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25): E4924-E4933.

33. Pisignano G., Napoli S., Magistri M., Mapelli S.N., Pastori C., Di Marco S., Civenni G., Albino D., Enriquez C., Allegrini S., Mitra A., D'Ambrosio G., Mello-Grand M., Chiorino G., Garcia-Escudero R., Varani G., Carbone G.M., Catapano C.V. A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers. Nat Commun. 2017 May 30;8: 15622.

32. Civenni G. Targeting Promoter-Associated Noncoding RNA In Vivo. Methods Mol Biol. 2017;1543: 259-270.

31. Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello-Grand M, Rossi S, Losa M, D'Ambrosio G, Sessa F, Thalmann GN, Garcia-Escudero R, Zitella A, Chiorino G, Catapano CV, Carbone GM. MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression
J Clin Invest. 2016 Dec 1; 126(12): 4585-4602.

30. Roos M, Pradère U, Ngondo RP, Behera A, Allegrini S, Civenni G., Zagalak JA, Marchand JR, Menzi M, Towbin H, Scheuermann J, Neri D, Caflisch A, Catapano CV, Ciaudo C, Hall J. A Small-Molecule Inhibitor of Lin28. ACS Chem Biol. 2016 Aug 22. [Epub ahead of print]

29. Albino D., Civenni G., Dallavalle C., Roos M., Jahns H., Curti L., Rossi S., Pinton S., D'Ambrosio G., Sessa F., Hall J., Catapano C.V., Carbone G.M.. Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer. Cancer Res. 2016 Jun 15;76(12):3629-43.

28. Civenni G., Longoni N., Costales P., Dallavalle C., García Inclán C., Albino D., Nuñez L.E., Morís F., Carbone G.M., Catapano C.V. .EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-κB. Mol Cancer Ther. 2016 May;15(5):806-18.

27. Roos M., Rebhan M.A., Lucic M., Pavlicek D., Pradere U., Towbin H., Civenni G., Catapano C.V., Hall J.Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells. Nucleic Acids Res. 2015 Jan 30;43(2):e9

26. Toso A., Revandkar A., Di Mitri D., Guccini I., Proietti M., Sarti M., Pinton S., Zhang J., Kalathur M., Civenni G., Jarrossay D., Montani E., Marini C., Garcia-Escudero R., Scanziani E., Grassi F., Pandolfi P.P., Catapano C.V., Alimonti A Enhancing chemotherapy efficacy in pten-deficient prostate tumors by activating the senescence-associated antitumor immunity. Cell Rep. 2014; 9(1): 75-89.

25. Barysch M., Levesque M.P., Cheng P., Karpova M., Mihic D., Civenni G., Shakhova O., Sommer L., Biedermann T., Schiestl C., Dummer R. Co-expression of SOX10/CD271 (p75NTR) and ß-galactosidase in large to giant congenital melanocytic nevi of pediatric patients. Dermatopathology 2014; 1: 35-46.

24. Civenni G., Malek A., Albino D., Garcia-Escudero R., Napoli S., Di Marco S., Pinton S., Sarti M., Carbone G.M, Catapano, C.V. RNAi-mediated silencing of Myc transcription inhibits stem-like cell maintenance and tumorigenicity in prostate cancer. Cancer Research, Published OnlineFirst September 24, 2013; doi: 10.1158/0008-5472.CAN-13-0615.

23. Longoni N., Sarti M., Albino D., Civenni G., Malek A., Ortelli E., Pinton S., Mello-Grand M., Ostano P., D'ambrosio G., Sessa F., Garcia-Escudero R., Thalmann G., Chiorino G., Catapano C. and Carbone G. ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-kB and drives prostate cancer progression. Cancer Res. 2013; doi: 10.1158/0008-5472.CAN-12-4537

22. Shakhova O., Zingg D., Schaefer S., Hari L., Civenni G., Blunschi J., Cladinot S., Barrandon Y., Okoniewski M., Beermann F., Mihic-Probst D., Reinhard D., Holger M., Wegener M., Cinelli P. and Sommer L. Sox10 promotes the formation and maintenance of giant congenital nevus and melanoma. Nature Cell Biology, 2012 Jul 8. doi: 10.1038/ncb2535. [Epub ahead of print]

21. Marmaras A., Lendenmann T., Civenni G., Franco D., Poulikakos D., Kurtcuoglu V., and Ferrari A. Topography-mediated apical guidance in epidermal wound healing. Soft Matter, 2012; 8, 2922–2930.

20. Albino D., Longoni N., Curti L., Mello-Grand M., Pinton S., Civenni G., Thalmann G.N., D'Ambrosio G., Sarti M., Sessa F., Chiorino G., Catapano C.V. and Carbone G.M. ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features. Cancer Res. 2012; 72(11): 2889-900.

19. Mihic-Probst D., Ikenberg K., Tinguely M., Schraml P., Behnke S., Seifert B., Civenni G., Sommer L., Moch H., Dummer R.. Tumor cell plasticity and angiogenesis in human melanomas. PLoS One. 2012;7(3):e33571.

18. Kiowski G., Biedermann T., Widmer D.S., Civenni G., Burger C., Dummer R., Sommer L. and Reichmann E. Engineering melanoma progression in a humanized environment in vivo. J Invest Dermatol. 2012; 132(1): 144-53.

17. Civenni G., Walter A., Kobert N., Mihic-Probst D., Belloni B., Seifert B., Moch H., Dummer R., van den Broek M. and Sommer L. Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-Term Growth. Cancer Res. 2011; 71(8): 3098-109.

16. Fuchs S, Herzog D, Sumara G, Büchmann-Moller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, and Sommer L. Stage-specific control of neural crest stem cell proliferation by the small Rho GTPases Cdc42 and Rac1. Cell Stem Cell, 2009; 4(3): 236-47.

15. Civenni G, Sommer L. Chemokines in neuroectodermal development and their potential implication in cancer stem cell-driven metastasis. Semin Cancer Biol. 2009; 19(2): 68-75.

14. Ayyannan A, Civenni G, Catherine M, Lefort K, Mandinova A, Raffoul W, Jayasree G, Dotto GP and Brisken C. Increased wnt signaling triggers oncogenic conversion of human breast epithelial cells by a notch-dependant mechanism. PNAS USA 2006; 103(10): 3799-804.

13. Holbro T, Civenni G, Hynes NE. The ErbB receptors and their role in cancer progression. Exp Cell Res. 2003; 284(1): 99-110.

12. Civenni G, Holbro T, Hynes NE. Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells. EMBO Rep. 2003; 4(2): 166-71.

11. Civenni G, Butikofer P, Stadelmann B, Brodbeck U. In vitro phosphorylation of purified glycosylphosphatidylinositol-specific phospholipase D. Biol Chem. 1999; 380(5): 585-8.

10. Civenni G, Bezzi P, Trotti D, Volterra A, Racagni G. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur J Pharmacol. 1999; 370(2): 161-7.

9. Butikofer P, Vassella E, Ruepp S, Boschung M, Civenni G, et al. Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane. J Cell Sci. 1999; 112: 1785-95.

8. Civenni G, Test ST, Brodbeck U, Butikofer P. In vitro incorporation of GPI-anchored proteins into human erythrocytes and their fate in the membrane. Blood. 1998; 91(5):1784-92.

7. Schousboe A, Sonnewald U, Civenni G, Gegelashvili G. Role of astrocytes in glutamate homeostasis. Implications for excitotoxicity. Adv Exp Med Biol. 1997; 429:195-206.

6. Gegelashvili G, Civenni G, Racagni G, Danbolt NC, Schousboe I, Schousboe A. Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. Neuroreport. 1996; 8(1): 261-5.

5. Perez J, Vezzani A, Civenni G, Tutka P, Rizzi M, Schupbach E, Hoyer D. Functional effects of D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2 and differential changes in somatostatin receptor messenger RNAs, binding sites and somatostatin release in kainic acid-treated rats. Neuroscience. 1995; 65(4): 1087-97.

4. Volterra A, Trotti D, Bezzi P, Civenni G, Racagni G. [Ca2+] modulates the ratio between cycloxygenase and lipoxygenase metabolism of arachidonic acid in homogenates of hippocampal astroglial cultures. Neurosci Lett. 1995; 183(3): 160-3.

3. Vezzani A, Civenni G, Rizzi M, Monno A, Messali S, Samanin R. Enhanced neuropeptide Yrelease in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats. Brain Res. 1994; 660(1): 138-43.

2. Consolo S, Baldi G, Russi G, Civenni G, Bartfai T, Vezzani A. Impulse flow dependency of galanin release in vivo in the rat ventral hippocampus. PNAS USA. 1994; 91(17): 8047-51.

1. Nano R, Civenni G, Marcotti W. Comparison of three histochemical methods for assaying lactate dehydrogenase in liver.Acta Histochem. 1992; 93(2): 446-52.

 
 
© 2019 Gianluca Civenni